Fluid Injection through Out-of-plane Microneedles
نویسندگان
چکیده
(1) Berkeley Sensor and Actuator Center – University of California at Berkeley – 497 Cory Hall – Berkeley, California, 94704 U.S.A. Tel +1 (510) 642 4876, Fax +1 (510) 643 6637, Email [email protected] (2) Berkeley Sensor and Actuator Center – University of California at Berkeley – 497 Cory Hall – Berkeley, California, 94704 U.S.A. Tel +1 (510) 642 9360, Fax +1 (510) 643 6637, Email [email protected]
منابع مشابه
Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions.
In this paper, we present design, fabrication and coupled multifield analysis of hollow out-of-plane silicon microneedles with piezoelectrically actuated microfluidic device for transdermal drug delivery (TDD) system for treatment of cardiovascular or hemodynamic disorders such as hypertension. The mask layout design and fabrication process of silicon microneedles and reservoir involving deep r...
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Infusion into skin using hollow microneedles offers an attractive alternative to hypodermic needle injections. However, the fluid mechanics and pain associated with injection into skin using a microneedle have not been studied in detail before. Here, we report on the effect of microneedle insertion depth into skin, partial needle retraction, fluid infusion flow rate and the co-administration of...
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BACKGROUND The present study was designed to evaluate the extent to which pretreatment with microneedles can enhance skin permeation of nanoparticles in vitro and in vivo. Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection. METHODS AND RESULTS ...
متن کاملPrecise microinjection into skin using hollow microneedles.
Hollow needles of micron dimensions have previously been fabricated and envisioned for use with transdermal patches or infusion pumps to achieve painless delivery of drugs to the skin for local and systemic effects without the need for hypodermic needles. However, little work has been carried out to identify methods to effectively use hollow microneedles for drug delivery. To address this need,...
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